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KMID : 0613820030130050627
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Journal of Life Science
2003 Volume.13 No. 5 p.627 ~ p.633
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Effcets of Bromate on the Glutathione Synthesis in Various Organs of Rats
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Kim Na-Young
Kang Hye-Ok
Lee Moo-Kang
Choi Jong-Won
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Abstract
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The effects of bromate administration on glutathione were studied in rats. The contents of glutathione in the liver and kidney were significantly decreased but the alteration was not significant in lung and blood by bromate adminstration. The decrease occurred without concomitant increases in oxidized glutathione (GSSG) or in the GSSG/ GSH+GSSG ratio. The activities of γ-glutamylcysteine synthetase in the liver and kidney were decreased by bromate administration. γ-Glutamyl transpeptidase activities was significantly decreased in the kidney and not significantly decreased in the lung of bromate treated-rats. These results suggest that the decreased synthesis of glutathione by bromate may be an important reason for the decreased level of glutathione in the liver and kidney, thus the decreased glutathione transport would be a factor on the changes of glutathione contents in bromate-treated rats.
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